Publikationen
1. Wagner, K., T.K., Lampe, M., Krieg, J., and Huber, A. (2022) Phospholipase D and retromer promote recycling of TRPL ion channel via the endoplasmatic reticulum. Traffic, 23(1), 42-62.
2. Schopf, K., Smylla, T. K., and Huber, A. (2019) Immunocytochemical labeling of rhabdomeric proteins in Drosophila photoreceptor cells is compromised by a light-dependent technical artifact. J. Histochem. Cytochem., 67 (10),745-757.
3. Fritsch, C., Bernardo-Garcia, F. J., Humberg, T.-H., Mishra, A. K., Miellet, S., Almeida, S., Frochaux, Michael V., Deplancke, B., Huber, A., and Sprecher, S.G. (2019) Multilevel regulation of the glass locus during Drosophila eye development. PLoS Genet., doi: https://doi.org/10.1371/journal.pgen.1008269 .
4. Smylla, T. K., Meier, M., Preiss, A., Maier, D. (2019) The Notch repressor complex in Drosophila: in vivo analysis of Hairless mutants using overexpression experiments. Dev. Genes Evol., 229: 13.
5. Voolstra, O., Strauch, L., Mayer, M., and Huber, A. (2018) Functional characterization of the three Drosophila retinal degeneration C (RDGC) protein phosphatase isoforms. PLoS One, 13 (9): e0204933., doi: 10.1371/journal.pone.0204933.
6. Strauch, L., Pfannstiel, J., Huber, A., and Voolstra, O. (2018) Solubility and subcellular localization of the three Drosophila RDGC phosphatase variants are determined by acylation. FEBS Lett., 592, 2403-2413. doi:10.1002/1873-3468.13163
7. Voolstra, O., Rhodes-Mordov, E., Katz, B., Bartels, J.-P., Oberegelsbacher, C., Schotthöfer, S. K., Yasin, B., Tzadok, H., Huber, A., and Minke, B. (2017) The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light in Vivo. J. Neurosci. 37, 4213-4224.
8. Katz, B., Voolstra, O., Tzadok, H., Yasin, B., Rhodes-Modrov, E., Bartels, J.-P., Strauch, L., Huber,A., and Minke, B. (2017) The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site. Channels, DOI: 10.1080/19336950.2017.1361073
9. Yasin, B., Kohn, E., Peters, M., Segura, R., Weiss, S., Katz, B., Schopf, K., Huber, A., and Minke, B. (2017) Ectopic expression of mouse melanopsin in Drosophila photoreceptors reveals fast response kinetics and persistent dark excitation. J. Biol. Chem 292, 3624-3636.
10. Strauch, L., Cerny, A., Belusic, G., and Huber, A. (2016) Oscillations in the ERG of the Drosophila trpl302 mutant are caused by an additional mutation in the inebriated gene. Drosophila Information Service 99, 8-11.
11. Spring, O.; Pfannstiel, J.;Klaiber, I.; Conrad, J.; Beifuss, U.; Apel, L.; Aschenbrenner, A.-K.; Zipper, R (2015) The nonvolatile metabolome of sunflower linear glandular trichomes Phytochem., doi: 10.1016/j.phytochem.2015.09.007
12. Cerny, A., Altendorfer, A., Schopf, K., Baltner, K., Maag, M., Sehn, E., Wolfrum, U., and Huber, A. (2015) The GTP- and phospholipid-binding protein TTD14 regulates trafficking of the TRPL ion channel in Drosophila photoreceptor cells. PLoS Genet., 11(10): e1005578.
13. Voolstra, O., Spät, P., Oberegelsbacher, C., Claussen, B., Pfannstiel, J., and Huber, A. (2015) Light-Dependent Phosphorylation of the Drosophila Inactivation No Afterpotential D (INAD) Scaffolding Protein at Thr170 and Ser174 by Eye-Specific Protein Kinase C. PLOS One, 10(3):e0122039.
14. Simon, O., Klebensberger, J., Mückschel, B., Klaiber, I., Graf, N., Altenbuchner, J., Huber, A., Hauer,B., and Pfannstiel, J. (2015) Analysis of the molecular response of Pseudomonas putida KT2440 to the next-generation biofuel n-butanol. J. Proteomics 122, 11-25.
15. Vallon, T., Simon, O., Rendgen-Heugle, B., Frana, S., Mückschel, B., Boicher, A., Siemann-Herzberg, M., Pfannstiel, J., Hauer, B., Huber, A., Breuer, M., and Takors, R. (2015) Applying systems biology tools to study n-butanol degradation in Pseudomonas Putida KT2440. Eng. Life Sci. 15, 760-771.
16. Holder, A.; Thienel, K.; Klaiber, I.; Pfannstiel, J.; Weiss, J.; Hinrichs, J. (2014) Quantification of bio- and techno-functional peptides in tryptic bovine micellar casein and ß-casein hydrolysates
Food Chemistry, doi: 10.1016/j.foodchem.2014.02.104
17. Simon, O., Klaiber, I., Huber, A., and Pfannstiel, J. (2014) Comprehensive proteome analysis of the response of Pseudomonas putida KT2440 to the flavor compound vanillin. J. Proteomics 109, 212-227.
18. Voolstra, O., Bartels, J.-P., Oberegelsbacher, C., Pfannstiel, J., and Huber, A. (2013) Phosphorylation of the Drosophila Transient Receptor Potential Ion Channel is Regulated by the Phototransduction Cascade and Involves Several Protein Kinases and Phosphatases. PLOS One, 8:e73787
19. Cerny, A.C., Oberacker, T., Pfannstiel, J., Weigold, S., Will, C., and Huber, A. (2013) Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability. J. Biol. Chem. 288, 15600-15613.
20. Katz, B., Oberacker, T., Richter, D., Tzadok, H., Peters, M., Minke, B., and Huber, A. (2013) The Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo. J. Cell Sci. 126, 3121-3133.
21. Schmitt-Engel, C., Cerny, A., Schoppmeier, M. (2012) A dual role for nanos and pumilio in anterior and posterior blastodermal patterning of the short-germ beetle Tribolium castaneum. Developmental Biology
22. Pickel B., Pfannstiel J., Steudle A., Lehmann A., Gerken U.,Pleiss J., Schaller A.
(2012) A Model of Dirigent Proteins Derived from Structural and Functional Similarities with Allene Oxide Cyclase and Lipocalins. FEBS Journal
23. Mückschel, B., Simon, O., Klebensberger, J., Graf, N., Rosche, B., Altenbuchner, J., Pfannstiel, J., Huber, A., and Hauer, B. (2012) Ethylene Glycol Metabolism by Pseudomonas putida. Appl. Env. Microbiol. 78, 8531-8539.
24. Bäumer, D., Trauner, J., Hollfelder, D., Cerny, A., Schoppmeier, M. (2011) JAK-STAT signalling is required throughout telotrophic oogenesis and short-germ embryogenesis of the beetle Tribolium. Developmental Biology
25. Richter, D., Katz, B., Oberacker, T., Tzarfaty, V., Belusic, G., Minke, B., and Huber, A. (2011) Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry J. Biol. Chem. 286, 34234-34243.
26. Oberegelsbacher, C., Schneidler, C., Voolstra, C., Cerny, A., and Huber, A. (2011) The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. Eur. J. Cell Biol. 90, 620-630.
27. Voolstra,O., Beck,K., Oberegelsbacher,C., Pfannstiel,J., and Huber,A. (2010). Light-dependent phosphorylation of the Drosophila transient receptor potential (TRP) ion channel. J. Biol. Chem. 285, 14275-14284.
28. Voolstra,O., Oberhauser,V., Sumser,E., Meyer,N.E., Maguire,M.E., Huber,A., and von Lintig, J. (2010). NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors. J. Biol. Chem. 285, 2130-2139.
29. Pickel, B.; Constantin, M.-A.; Pfannstiel, J.; Conrad, J.; Beifuss, U., Schaller, A. (2010) An enantiocomplementary dirigent protein for the enantioselective, laccase-catalyzed oxidative coupling of phenols. Angewandte Chemie Internationale Edition
30. Mika, S., Mert-Balci, F., Klaiber, I., Pfannstiel, J., Möller, W., Rösner, H., Förster-Fromme, K., Beifuss, U. (2009) Flavonoid Glucuronides and a Chromone from the Aquatic Macrophyte Stratiotes aloides
J. Nat. Prod.
31. Kemmler, S., Stach, M., Knapp, M., Ortiz, J., Pfannstiel, J., Ruppert, T., Lechner, J.
(2009) Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling.
EMBO J.
32. Ivanova, Antoaneta; Mikhova, Bozhanka; Klaiber, Iris; Dinchev, Dragomir; Kostova, Ivanka (2009) Steroidal saponins from Smilax excelsa rhizomes
Natural Product Research, Part A: Structure and Synthesis
33. Cedzich, A., Huttenlocher, F., Kuhn, B.M., Pfannstiel, J., Gabler, L., Stintzi, A., Schaller, A. (2009) The protease-associated (pa) domain and C-terminal extension are required for zymogen processing, sorting within the secretory pathway, and activity of tomato subtilase 3 (SLSBT3). J. Biol. Chem.
34. Meyer, N.E., Oberegelsbacher, C., Dürr, T.D., Schäfer, A., Huber, A. (2008). An eGFP-based genetic screen for defects in light-triggered subcelluar translocation of the Drosophila photoreceptor channel TRPL. Fly 2, 384-394.
35. Vitus Oberhauser, Olaf Voolstra, Annette Bangert, Johannes von Lintig, Klaus Vogt (2008) NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide. PNAS
36. Cerny, A.C., Grossmann, D., Bucher, G. and Klingler, M. (2008) The Tribolium ortholog of knirps and knirps-related is crucial for head segmentation but plays a minor role during abdominal patterning Developmental Biology
37. Conrad, J.; Mongkolvisut, W.; Sutthivaiyakit, S.; Leutbecher, H.; Mika, S.; Klaiber, I.; Möller, W.; Rösner, H.; Beifuss, U. (2007) Cyclic Heptapeptides from the latex of Jatropha integerrima. Planta Medica
38. Schmidt, D.; Conrad, J.; Mika, S.; Klaiber, I.; Beifuss, U. (2007) Efficient synthesis of natural products with a 3,6-disubstituted 4-hydroxy-2H-pyran-2-one framework
Planta Medica
39. Meyer, N.E., Joel-Almagor, T., Frechter, S., Minke, B., and Huber, A. (2006). Subcellular translocation of eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J. Cell Sci., 119, 2592-2603.
40. Grosshans BL, Grotsch H, Mukhopadhyay D, Fernandez IM, Pfannstiel J, Idrissi FZ, Lechner J, Riezman H, Geli MI. (2006) TEDS Site Phosphorylation of the Yeast Myosins I Is Required for Ligand-induced but Not for Constitutive Endocytosis of the G Protein-coupled Receptor Ste2p. J Biol Chem.
41. Chorna-Ornan, I., Tzarfaty, V., Ankri-Eliahoo, G., Joel-Almagor, T., Meyer, N., Huber, A., Payre, F., and Minke, B. (2005) Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors. J. Cell. Biol. 171, 143-152.
42. Cerny, A.C., Bucher, G., Schröder, R. and Klingler, M. (2005) Breakdown and abdominal patterning in the Tribolium Krüppel mutant jaws. Development
43. Zschocke, S.; Klaiber, I.; Bauer, R.; Vogler, B. (2005) HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phtalides in Ligusticum chuanxiong Molecular Diversity
44. Schmitt, A., Vogt, A., Friedmann, K., Paulsen, R, and Huber, A. (2005) Rhodopsin patterning in central photoreceptor cells of the blowfly Calliphora vicina: Cloning and characterization of Calliphora rhodopsins Rh3, Rh5, and Rh6. J. Exp. Biol. 208, 1247-1256.
45. Schillo, S., Belusic, G., Hartmann, K., Franz, C., Kühl, B., Brenner-Weiß, G., Paulsen, R., and Huber, A. (2004) Targeted mutagenesis of the farnesylation site of Drosophila Gge disrupts membrane association of the G protein bg complex and affects the light-sensitivity of the visual system. J. Biol. Chem. 279, 36309-36316.
46. Williams, L. A. D.; Vasquez, E.; Klaiber, I.; Kraus, W.; Rosner, H. (2003) A sulfonic anhydride derivate from dibenzyl trisulfide with agro-chemical avtivities. Chemosphere
47. Spring, Otmar; Zipper, Reinhard; Conrad, Jürgen; Vogler, Bernhard; Klaiber, Iris; Da Costa, Fernando B. (2003) Sesquiterpene lactones from glandular trichomes of Viguiera radula (Heliantheae; Asteraceae). Phytochemistry
48. Harteneck, C., Kuchta, S. N., Huber, A., Paulsen, R., and Schulz, G. (2002) The PDZ-scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP. FASEB J. 10.1096/fj.02-0192fje.
49. Bähner, M., Frechter, S., Da Silva, N., Minke, B., Paulsen, R., and Huber, A. (2002) Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron 34, 83-93.
50. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature
51. Pfannstiel J, Cyrklaff M, Habermann A, Stoeva S, Griffiths G, Shoeman R, Faulstich H. (2001) Human cofilin forms oligomers exhibiting actin bundling activity. J Biol Chem.
52. Gommel DU, Memon AR, Heiss A, Lottspeich F, Pfannstiel J, Lechner J, Reinhard C, Helms JB, Nickel W, Wieland FT. (2001) Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. EMBO J.
53. Huber, A., Belusic G., Da Silva, N., Bähner, M., Gerdon, G., Draslar, K., and Paulsen, R. (2000) The Calliphora rpa mutant lacks the PDZ domain assembled INAD signaling complex. Eur. J. Neurosci. 12, 3909-3918.
54. Bähner, M., Sander, P., Paulsen, R., and Huber, A. (2000) The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Gaq to phospholipase Cb. J. Biol. Chem. 275, 2901-2904.
55. Defacque H, Egeberg M, Habermann A, Diakonova M, Roy C, Mangeat P, Voelter W, Marriott G, Pfannstiel J, Faulstich H, Griffiths G. (2000) Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J.
56. Tiepold M, Kliche W, Pfannstiel J, Faulstich H. (2000) Stepwise modulation of ATPase activity, nucleotide trapping, and sliding motility of myosin S1 by modification of the thiol region with residues of increasing size. Biochemistry.
57. Paulsen, R., Bähner, M., and Huber, A. (2000) The PDZ assembled „transducisome“ of microvillar photoreceptors: the TRP/TRPL problem. Eur. J. Physiol. 439, 181-183.
58. Schulz, S., Huber, A., Schwab, K., and Paulsen, R. (1999) A novel Gg isolated from Drosophila constitutes a visual G protein g subunit of the fly compound eye. J. Biol. Chem. 274, 37605-37610.
59. Salcedo, E., Huber, A., Henrich, S., Chadwell, L.V., Chou, W.-H., Paulsen, R., and Britt, S. G. (1999) Blue and green absorbing visual pigments of Drosophila: Ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins. J. Neurosci. 19, 10716-10726.
60. Chou, W.-H., Huber, A., Bentrop, J., Schulz, S., Schwab, K., Chadwell, L. V., Paulsen, R., and Britt, S. G. (1999) Patterning of the R7 and R8 photoreceptor cells of Drosophila: Evidence for induced and default cell-fate specification. Development 126, 607-616.
61. Kliche W, Pfannstiel J, Tiepold M, Stoeva S, Faulstich H. (1999) Thiol-specific cross-linkers of variable length reveal a similar separation of SH1 and SH2 in myosin subfragment 1 in the presence and absence of MgADP. Biochemistry.
62. Huber, A., Sander, P., Bähner, M., and Paulsen, R. (1998) The TRP Ca2+ channel assembled in a signaling complex by the PDZ-domain protein INAD is phosphorylated through the interaction with protein kinase C (ePKC) FEBS Lett. 425, 317-322.
63. Huber, A., Schulz, S., Bentrop, J., Groell, C., Wolfrum, U., and Paulsen, R. (1997) Molecular cloning of Drosophila Rh6: the visual pigment of a subset of R8 photoreceptor cells. FEBS Lett. 406, 6-10.
1996
Huber, A., Sander, P., Gobert, A., Bähner, M., Hermann, R., and Paulsen, R. (1996) The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J. 15, 7036-7045.
Huber, A., Sander, P., Wolfrum, U., Groell, C., Gerdon, G., and Paulsen, R. (1996) Isolation of genes encoding photoreceptor-specific proteins by immunoscreening with antibodies directed against purified blowfly rhabdoms. J. Photochem. Photobiol. B. 35, 69-76.
Huber, A., Sander, P., and Paulsen, R. (1996) Phosphorylation of the InaD gene product, a photoreceptor membrane protein required for recovery of visual excitation. J. Biol. Chem. 271, 11710-11717.
1994
Huber, A., Wolfrum, U., and Paulsen, R. (1994) Opsin maturation and targeting to rhabdomeral photoreceptor membranes requires the retinal chromophore. Eur. J. Cell Biol. 63, 219-229.
1990
Huber, A., Smith, D.P., Zuker, C.S., and Paulsen, R. (1990) Opsin of Calliphora peripheral photoreceptors R1-6: homology with Drosophila Rh1 and post-translational processing. J. Biol. Chem. 265, 17906-17910.
1. Wagner, K., Smylla, T. K., Zeger, M., Huber, A. (2022) Studying Membrane Protein Trafficking in Drosophila Photoreceptor Cells Using eGFP-Tagged Proteins. J. Vis. Exp. (179), e63375, doi:10.3791/63375.
2. Smylla, T.K., Wagner, K, and Huber, A. (2021) Application of fluorescent proteins for functional dissection of the Drosophila visual system. Int. J. Mol. Sci., 22 (16), 8930, doi: 10.3390/ijms22168930
3. Voolstra, O., and Huber, A. (2020) Ca2+ Signaling in Drosophila Photoreceptor Cells. In: Islam M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 1131, Springer, Cham.-757.
4. Voolstra, O., and Huber, A. (2019) Ca2+ signaling in Drosophila photoreceptor cells. Advances in Experimental Medicine and Biology, DOI: 10.1007/978-3-030-12457-1_34.
5. Schopf, K. and Huber, A. (2017) Membrane protein trafficking in Drosophila photoreceptor cells. Eur. J. Cell Biol., 96 (5), 391-401., DOI: 10.1016/j.ejcb.2016.11.002
6. Voolstra, O. and Huber, A. (2014) Post-translational modifications of TRP channels. Cells 3, 258-287. DOI: 10.3390/cells3020258
7. Cerny, A. and Huber, A. (2011) Regulation of TRP signaling by ion channel translocation between cell compartments. Advances in Experimental Medicine and Biology 704, 545-572., DOI: 10.1007/978-94-007-0265-3_30
8. Huber, A. (2004) Invertebrate phototransduction: Multimolecular signaling complexes and the role of TRP and TRPL channels. In Transduction channels in sensory cells (S. Frings and J. Bradley, eds.), WILEY-VCH, Weinheim, pp. 179-206., DOI:10.1002/3527603913.ch8
9. Huber, A. (2001) Scaffolding proteins organise multimolecular protein complexes for sensory signal transduction. Eur. J. Neurosci. 14, 769-776., DOI: 10.1046/j.0953-816x.2001.01704.x
10. Paulsen, R., Bähner, M., Huber, A., Schillo, M., Schulz, S., Wottrich, R., and Bentrop, J. (2001) The molecular design of a visual cascade: Molecular stages of phototransduction in Drosophila. In Vision: The approach of biophysics and neurosciences (C. Musio, ed.), World Scientific, Singapure, New Jersey, London, Hong Kong, pp. 41-59.
11. Paulsen, R., Bähner, M., Bentrop, J., Schillo, M., Schulz, S., and Huber, A. (2001) The molecular design of a visual cascade: Assembly of the Drosophila phototransduction pathway into a supramolecular signaling complex. In Vision: The approach of biophysics and neurosciences (C. Musio, ed.), World Scientific, Singapure, New Jersey, London, Hong Kong, pp. 60-73., https://doi.org/10.1142/9789812799975_0005
1. Huber, A. and Meyer, N. (2008) INAD signalling complex of Drosophila photoreceptors. In Visual Transduction and Non-Visual Light Perception (Tombran-Tink, J., Barnstable, C.J. eds.). Humana Press, Totowa (USA), pp. 267-284.
2. Schulz, S., Huber, A., Sander P., and Paulsen, R. (2001) Isolation of novel eye-specifically expressed genes by differential hybridization of a retinal cDNA library of Calliphora vicina. In Vision: The approach of biophysics and neurosciences (C. Musio, ed.), World Scientific, Singapure, New Jersey, London, Hong Kong, pp. 107-115.
3. Huber, A. and Paulsen, R. (1998) Regulation of rhodopsin expression in rhabdomeral photoreceptors: Functional analysis of the 5'flanking region of the Calliphora Rh1 opsin gene. In Photostasis and Related Phenomena (T. P. Williams and A. B. Thistle eds.) Plenum Press, New York, London, pp. 49-62.
4. Huber, A. and Paulsen, R. (1992) Glycosylation of dipteran opsins during membrane biogenesis. In Signal Transduction in Photoreceptor Cells (P.A. Hargrave, K.P. Hofmann, and U.B. Kaupp eds.) Springer Verlag Berlin, Heidelberg, New York, Tokyo, pp. 299-307.